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It is well known that health of the inhabitants is a visual indicator of social prosperity and an important ground for national security. For the formation of healthy society it is crucially important to develop modern medical technologies. In this view high importance is attached to preventive measures and early diagnostics of diseases, which decreases the costs of treatment and provides final economic effect.

It should be noted that stable isotopes based methods of medical diagnostics, such as positron-emission tomography (PET) and diagnostic breath test methods (DTM) find wide clinical application today.

The diagnostic substrate F‑18 – fluorodeoxyglucose is made from the fluor‑18 isotope obtained from water enriched with O‑18 isotope in cyclotron. 18F-fluorodeoxyglucose is used at molecular level to detect pathological changes in the patient's body at an early stage of oncological, nervous and cardiovascular diseases.

Increased interest in PET is explained by its wide possibilities in medical diagnostics and approachability in use. Positron emission tomography is a new unique means, providing opportunity to determine precisely, quickly, non-invasively any pathology in neurology, oncology, cardiology, endocrinology, etc. in ambulatory conditions. In contrast to classic methods of examination (X-ray, ultrasonic, computer and NM tomography), which show the body organ structure and its changes PET precisely record preceding phenomena – changes in metabolic processes. PET enables to disclose the earliest possible pathologic shifts far before morphological changes occur, which is especially important in the diagnostics of tumors and metastases, inflammation processes, myocardium, epilepsy, and a lot of other diseases. In particular, PET is the only instrument in the world, which provides opportunity to disclose malignant tumors at the so-called “zero” stage.

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